Fecal Microbiota Transplant

Fecal Microbiota Transplant – Dr. Antonio DeCarli

Fecal transplantation (or bacteriotherapy) is the transfer of stool from a healthy donor into the gastrointestinal tract for the purpose of treating recurrent C. difficile colitis.

 Fecal Microbiota Transplant (FMT) is a procedure in which fecal matter, or stool, is collected from a tested donor, mixed with a saline or other solution, strained, and placed in a patient, by colonoscopy, endoscopy, sigmoidoscopy, or orally in a capsule.

The purpose of fecal transplant is to replace good bacteria that has been killed or suppressed, usually by the use of antibiotics, causing bad bacteria, specifically Clostridium difficile, or C. diff., to over-populate the colon. This infection causes a condition called C. diff. colitis, resulting in often debilitating, sometimes fatal diarrhea.

C. difficile is a really nasty gut infection. It’s the most common hospital-acquired infection in the U.S. Half a million Americans get it every year. And it’s pretty resilient to antibiotics. About one in five people will get these recurring infections — so they’ll take antibiotics, then the infection will come back — at that point, they try antibiotics again, and the chances of the infection coming back are even greater. For those folks who get into these multiple recurrent cycles of infection, it turns out that fecal transplants work about 90 percent of the time to get rid of the infection.

History of FMT

Fecal transplant was first documented in 4th century China, known as “yellow soup”. It has been used for over 100 years in veterinary medicine, and has been used regularly for decades in many countries as the first line of defense, or treatment of choice, for C. diff.  It is customary in many areas of the world for a newborn infant to receive a tiny amount of the mother’s stool by mouth, thought to provide immediate population of good bacteria in the baby’s colon, thereby jump-starting the baby’s immune system.

Highly Effective Treatment – up to a 90% success rate!

Fecal Transplant is affordable, low-risk, highly effective treatment. It is not currently covered by most insurance companies, as it is still classified as an experimental treatment. Microbiota Restoration Therapy or FMT is now offered at Gastro Center of Florida under the medical care of Dr. Anthony DeCarli.

CDI Symptoms?

Symptoms of Clostridium difficile infection include profuse watery diarrhea, abdominal pain and tenderness, fever and loss of appetite. The term for the diarrhea resulting from CDI is Clostridium difficile-associated (CDAD).

Fecal Donor

Open Biome, a brilliant and compassionate group of scientists from MIT, Harvard, and Princeton, who have formed a 501c(3) to develop a donor stool bank which provides tested, frozen, and ready to use donor stool to doctors such as Dr. DeCarli for use in fecal transplant for C. difficile not responding to standard treatment, at a very reasonable cost.